Journal of thoracic and cardiovascular surgery

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It allows continued monitoring of the benefit-risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions journal of thoracic and cardiovascular surgery www. Overdosage with metronidazole appears to be associated with very few abnormal signs or symptoms.

Disorientation, ataxia and vomiting journal of thoracic and cardiovascular surgery occur, especially after ingestion of large amounts. In case of suspected massive overdosages, a symptomatic and supportive treatment should be instituted. Single oral doses of metronidazole, up to 12 g, have been reported in suicide attempts and accidental overdoses. There is no specific antidote for metronidazole overdosage.

In cases of suspected overdosage, a symptomatic and supportive treatment should be instituted. For information on the management of overdose, contact the Poison Information Centre on 131126 (Australia) or the National Poisons Centre, 0800 POISON or 0800 764 766 (New Zealand). Pharmacotherapeutic group: Antibacterials for systemic use, ATC code J01X D01. Specific bactericidal activity against important obligate anaerobes.

Metronidazole is effective in vitro against several species of anaerobic bacteria, particularly Bacteroides fragilis and other species of Bacteroides, and other species such as Fusobacteria, Eubacteria, Clostridia and anaerobic Streptococci. The MIC for most susceptible anaerobes is Note. Metronidazole is active against a wide range of pathogenic microorganisms, notably Trichomonas vaginalis and other trichomonads, Entamoeba histolytica, Giardia lamblia, Balantidium coli and the causative organisms of acute ulcerative gingivitis.

Maximum concentrations occur in the serum 1 to 2 hours after oral administration and at the end of the infusion after intravenous administration. Traces are detected after 24 hours. The biological half-life of oral and intravenous metronidazole has been determined as 6 to 7 and 7.

When administered in suppository form, metronidazole is absorbed slowly and less completely than the oral tablets. Peak serum levels are achieved in approximately 8 hours. After 500 mg and 1 g suppositories, the peak serum levels averaged 5.

Its elimination half-life was similar to the intravenous infusion, viz approximately 7. Metronidazole is widely distributed in body tissues and fluids. It diffuses across the blood brain barrier and placenta and is found in the breast milk of nursing mothers in concentrations equivalent to those in serum. It is not protein bound to any significant degree.

Most of the dose is excreted in the urine as metronidazole and its metabolites, including journal of thoracic and cardiovascular surgery oxidation products and glucuronides. In studies on the mutagenic potential journal of thoracic and cardiovascular surgery metronidazole, the Ames test was positive while several nonbacterial tests in animals were negative. In the patients with Crohn's disease, metronidazole increased the chromosome abnormalities in circulating lymphocytes.

The use of metronidazole for longer treatment than usually required should be carefully weighed (see Section 4. Metronidazole been shown to be tumorigenic and carcinogenic in rodents.

Maize starch, calcium hydrogen phosphate, povidone, hypromellose, magnesium stearate, macrogol 400 and new years day alone talc (400 mg tablets only). Incompatibilities were either not assessed or not identified as part of the registration of this medicine.

In Australia, information on the shelf life can be found on the public summary of the Australian Register of Therapeutic Goods (ARTG). The expiry date can be found on the roche posay shampoo. In Australia, any unused medicine or waste material should be disposed of by taking to your local pharmacy.

Metronidazole is a 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole. Metronidazole in a saturated aqueous solution has a pH of between 6 and journal of thoracic and cardiovascular surgery. What is in this leaflet This leaflet answers some common questions about Flagyl.

It does not contain all the available information.



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